The 2021 ORCA High School (Grades 9-12) Winner is The Poet X by Elizabeth Acevedo.

The 2021-22 ORCA High School (Grades 9-12) Division nominees are:
- Butterfly Yellow by Thanhha Lai
- The Field Guide to the North American Teenager by Ben Philippe
- Laura Dean Keeps Breaking Up with Me by Mariko Tamaki with illustrations by Rosemary Valero-O’Connell
- Lovely War by Julie Berry
- On the Come Up by Angie Thomas
- Opposite of Always by Justin A. Reynolds
- Patron Saints of Nothing by Randy Ribay
- With the Fire on High by Elizabeth Acevedo